A short history in bioinformatics Essay

Due to the influx of information from numerous research studies conducted by scientists under the coverage of Molecular Biology, the ongoing process has fueled the need for the development of a system that shall be able to organize and collate information – that is, Bioinformatics. From Tiselius’ design of the process of electrophoresis, to the development of the alpha-helix by Pauling and Corey, and consequently the improvement of Pauling and Corey’s model to the double-helix by Watson and Crick, developments on protein crystallography, the creation of the Advanced Research Projects Agency Network or ARPANET, the creation of molecular models, and so on, these various events and situations were taken collectively developing the need and recommendation for the creation of a model or framework that will handle information simultaneously, efficiently, and reliably. (Sadek, 2004) From the developments and discoveries of new information based on the processes and techniques employed in the field of Molecular Biology, supported by the attention and interest granted to computers and technology during the eighties because of the dawn of the era of technology, the role of Bioinformatics was realized, emphasized, and consequently developed. Scientists, as well as various organizations, industries, academic institutions, and such, have continued to develop and improve Bioinformatics. The results constitute the engineering of various applications or softwares since the concept of Bioinformatics was framed during the seventies. Each program or application that was structured were designed to carry out multifarious and specific tasks and responsibilities including DNA sequencing or mapping, the organization of data according to priorities, use, needs, concerns, problems, etc. Some of these applications or softwares include the PC/GENE, PROSITE, SEQANALREF, etc. (Agarwal, 200-) At present time, Bioinformatics continue to evolve and develop as man consciously obtains more complex information and experience developments from previous knowledge and established theories or concepts. In addition, as numerous problems and conflicts related to Biology and its practical application including lessons or concepts arise, Bioinformatics as a practical and essential field in Science and Technology will continue to look for solutions in order to address these concerns. The changing landscape of society, particularly its move from traditionalism and individualism to modernization and globalization, influences changes and transformations in Bioinformatics. BIOINFORMATICS: Molecular Biology, Computer Science, IT, and Statistics In order to deeply understand how Bioinformatics work, we need to go over the structure and features of the subfields that it constitutes, such as Molecular Biology, Computer Science, IT, and Statistics. Molecular Biology is a branch of Science that deals with the analysis of various molecules within living things in general. Various types of cells from man, animals, and plants are studied and analyzed in order to determine molecular compositions, and consequently learn determine their structures and compositions, their reactions to other molecules and substances found within living things, their functions and contributions to human life, or life in general including plants and animals, and so on. Molecular Biology also studies Deoxyribonucleic Acid or DNA compositions of living things as they contribute knowledge and information on Genetics. This particular aspect focuses on structuring how molecules reproduce through DNA replication within a cell. (Hyman, 2003) Computer Science and IT are both products of the fusion between Science and Technology. They function because of the build-up of information that constitutes Molecular Biology for the purposes of quantifying and qualifying facts and data into meaningful sequences, models, or formations that may be interpreted, analyzed, and synthesized. Some of the specific contributions of Computer Science and IT include the storage, construction, and reconstruction of DNA sequences, a thorough genome analysis by accessing various related information in databases managed by IT, the construction of graphic organizers or visual representations of information for clarity and direct presentation of facts, the timely and efficient transfer and receipt of information across databases and information systems, and the collation of variable information about protein sequences. (Keedwell & Narayanan, 2005) Statistics, as a mathematical and scientific approach to analyzing and interpreting data, contributes to Bioinformatics by allowing scientists to test the weight or magnitude of information and provide quantifiable data that may be interpreted according to established standards or guidelines. Information, facts, or data, obtained through experiments and consequently, the findings obtained by molecular biologists from thorough analysis and evaluation an in depth research studies are labeled with values leading to the formulation of estimates, predictions, or likelihoods of the occurrence of various phenomena. Moreover, Statistics is important in allowing computers and various technologies to determine how facts or data are to be translated in order to arrive at scientific conclusions of generalizations. (Ramsden, 2004) By and large, the unique features and contributions of these fields in Science, Technology, and Mathematics, meld together in order to build the foundations of Bioinformatics. Information from Molecular Biology are utilized and transformed to numerical data through Statistics, and both informational statements and figures are stored in computers and other technologies including IT systems or processes, IT functions, standards, guidelines, etc. for easy access and retrieval, synthesis, analysis, and interpretation, and are consequently managed through IT systems and processes. BIOEDIT BioEdit is a software application made available for Windows Operating Systems that is used to reconstruct how DNA, nucleic acids, and amino acids are arranged in order to follow the superlative sequence of these substances based on rules and standards derived from previous studies and analyses by molecular biologists and geneticists. Aside from these functions, BioEdit also runs to provide users with graphic simulators that construct drawings or illustrations, chartings and mappings, etc. , BLAST searches, and alignments. (Salemi & Vandamme, 2003 and Tsai, 2002)